Two cases of focal epithelial hyperplasia were observed in Tehran, Iran. No cases had been reported previously in the literature in Iran. The patients whose cases are presented were both white females. Multiple nodular lesions were seen on the upper and lower labial and buccal mucosa. The lesions were clinically and histologically consistent with focal epithelial hyperplasia (Heck's disease). No further treatment was undertaken as the lesions usually regress spontaneously.