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J Am Dent Assoc, Vol 115, No 1, 38-42.
© 1987 American Dental Association
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Journal of the American Dental Association, Vol 115, Issue 1, 38-42
Copyright © 1987 by American Dental Association

Clinical Trial

Oral acyclovir and herpes labialis: a randomized, double-blind, placebo-controlled study



GW Raborn, WT McGaw, M Grace, LD Tyrrell, and SM Samuels

A study of the effects of oral acyclovir (200 mg), administered five times per day for 5 days in 210 patients who cultured positive for herpes labialis, is made. A total of 149 patients were followed through three episodes each of herpes labialis while taking a placebo or acyclovir. Patients were evaluated for several clinical parameters, including the loss of lesion crust and reduction of the size of the area of the lesion between day 1 and day 5. Acyclovir showed a significant antiviral effect. Results show that oral acyclovir can favorably affect some parameters, but that higher doses or a "loading dose" could improve its efficacy.


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