The central giant-cell granuloma is a benign, fairly uncommon lesion that can appear clinically and radiographically similar to many other lesions. When histopathological examination discloses a giant-cell lesion of bone, clinical, radiographic, and laboratory data must be obtained and carefully analyzed to rule out such conditions as hyperparathyroidism, Paget's disease, and cherubism, and to confirm the diagnosis of central giant-cell granuloma. Once the diagnosis is established, thorough curettage or surgical excision of the tumor is recommended to assure complete removal. Although recurrence is rare, periodic postoperative examination is also suggested.