The Journal of the American Dental Association
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J Am Dent Assoc, Vol 118, No 6, 709-711.
© 1989 American Dental Association
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Journal of the American Dental Association, Vol 118, Issue 6, 709-711
Copyright © 1989 by American Dental Association

Journal Article

Salivary inhibition of HIV-1 infectivity: functional properties and distribution in men, women, and children



PC Fox, A Wolff, CK Yeh, JC Atkinson, and BJ Baum
Clinical Studies Unit, National Institute of Dental Research, 1B-21, Bethesda, MD 20892.

Human salivary gland secretions inhibit infection of human lymphocytes by the human immunodeficiency virus 1 (HIV-1), the causative agent of the acquired immune deficiency syndrome (AIDS). This activity was found in saliva collected directly from the orifice of the major salivary gland ducts and the whole saliva of healthy male volunteers. In the current report, the observations on salivary secretions are expanded to a greater number of individuals, including healthy women and children, and men infected with HIV-1.


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