At least 40 young women have died at the hands of a serial killer in what has been called the Green River Murders. Because most of the victims' remains were severely decomposed with partial or complete skeletonization and little or no personal effects were recovered, forensic odontologic methods played a key role in their identifications. Although numerous methods were used to accumulate leads to the identities of the badly decomposed skeletonized remains, leads generated through traditional investigative methods established the identities in most cases. Of 40 victims, 36 have now been identified, mainly by means of dental evidence. This article details the challenges presented by serial homicides and the key role of forensic odontologic methods in the Green River Murders investigation.