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J Am Dent Assoc, Vol 137, No 1, 54-60.
© 2006 American Dental Association
Essential Dental System, Inc.
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CLINICAL PRACTICE

CASE REPORT

JADA Continuing Education

Diagnosis of systemic sarcoidosis prompted by orofacial manifestations

A review of the literature



Mahnaz Fatahzadeh, DMD and Joseph Rinaggio, DDS, MS

Background. Sarcoidosis is a multifactorial systemic inflammatory disorder of unknown origin characterized by many potential signs and symptoms, as well as by the presence of noncaseating granulomas in the organs involved. Sarcoidosis also may manifest in the oral and maxillofacial region.

Case Description. The authors describe a patient with xerostomia, dysgeusia, oral burning, xerophthalmia and bilateral parotid enlargement. She was diagnosed as having systemic sarcoidosis on the basis of the histologic findings of a biopsy of the labial minor salivary gland, as well as subsequent diagnostic evaluations.

Conclusion and Clinical Implications. Enlargement of major salivary glands may be the first sign of sarcoidosis in a patient with few other symptoms or clinical findings suggestive of the disease. This case emphasizes the importance of including sarcoidosis in the differential diagnosis of bilateral parotid swelling associated with xerostomia. It also highlights the dentist’s potential role in the diagnosis and dental treatment of patients with systemic sarcoidosis.

Key Words: Parotid enlargement; xerostomia; sarcoidosis; granulomatous inflammation




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