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J Am Dent Assoc, Vol 137, No 8, 1115-1119. © 2006 American Dental Association

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JADA Continuing Education

Background. Bisphosphonates are becoming recognized increasingly as having a significant impact on dental therapies. This case report describes adverse clinical sequelae and successful treatment following periodontal surgery in a dental patient receiving bisphosphonate treatment.

Case Description. A 78-year-old woman experienced a nonhealing interproximal wound subsequent to a minor periodontal procedure performed to facilitate restoration of an adjacent tooth. Her medical history revealed that she had been taking an oral bisphosphonate every day for the previous five years for treatment of osteoporosis. After three months of periodic débridement and meticulous oral home care, one of the authors recovered a large piece of necrotic bone. The wound healed after the author performed surgery at the site.

Clinical Implications. Dentists should exercise caution when considering surgical procedures for patients with a history of oral bisphosphonate use. Thorough treatment of nonhealing wounds in these patients can lead to favorable outcomes.

Key Words: Osteonecrosis of the jaw; bisphosphonate; systemic drug side effects; osteoporosis

This article has been cited by other articles:

				V. Kumar, B. Pass, S. A. Guttenberg, J. Ludlow, R. W. Emery, D. A. Tyndall, and R. J. Padilla Bisphosphonate-related osteonecrosis of the jaws: A report of three cases demonstrating variability in outcomes and morbidity J Am Dent Assoc, May 1, 2007; 138(5): 602 - 609. [Abstract] [Full Text] [PDF]

				P. A. Fugazzotto and S. Lightfoot Oral bisphosphonates and bon. J Am Dent Assoc, November 1, 2006; 137(11): 1498 - 1499. [Full Text] [PDF]

				K. M. Hargreaves and M. Balson Findings questioned. J Am Dent Assoc, November 1, 2006; 137(11): 1496 - 1497. [Full Text] [PDF]

				N. D. Russo An alternative explanation. J Am Dent Assoc, November 1, 2006; 137(11): 1497 - 1497. [Full Text] [PDF]