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J Am Dent Assoc, Vol 139, No 5, 581-585.
© 2008 American Dental Association
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CLINICAL PRACTICE

Recognizing Doxycycline-Induced Esophageal Ulcers in Dental Practice

A Case Report and Review



Stuart L. Segelnick, DDS, MS and Mea A. Weinberg, RPh, DMD, MSD

Background. Doxycycline-induced esophageal ulcer is a documented adverse drug reaction. Unfortunately, many health care professionals are not familiar with this particular drug reaction. Because doxycycline frequently is prescribed in the clinical practice of periodontics, it is important for dentists to be aware of this potential drug reaction.

Methods. The authors describe the case of a patient who was taking doxycycline after undergoing periodontal surgery and experienced a complication. The diagnosis revealed that the patient had developed an esophageal ulcer as a result of taking the doxycycline.

Results. The patient’s esophageal ulcer resolved with the aid of dietary changes and a prescription of rabeprazole, a proton pump inhibitor.

Conclusions and Clinical Implications. The etiology of doxycycline-induced esophageal ulceration is complex, and proper diagnosis is essential for its resolution. Dentists should be aware of the potential for this adverse drug reaction.

Key Words: Drug injuries; doxycycline; esophageal ulcer; patient education; adverse drug reaction; dentistry

Abbreviations: GI: Gastrointestinal.






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