The Journal of the American Dental Association
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Am Dent Assoc, Vol 139, No 7, 915-924.
© 2008 American Dental Association
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Azarpazhooh, A.
Right arrow Articles by Limeback, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Azarpazhooh, A.
Right arrow Articles by Limeback, H.

CLINICAL PRACTICE

JADA Continuing Education

Clinical Efficacy of Casein Derivatives

A Systematic Review of the Literature



Amir Azarpazhooh, DDS, MSc and Hardy Limeback, BSc, PhD, DDS

Background. The objective of this article was to review systematically the clinical trials of casein derivatives (specifically casein phosphopeptide–amorphous calcium phosphate [CPP-ACP] complex) used in dentistry.

Types of Studies Reviewed. The authors included clinical studies that examined the efficacy of casein derivatives in dentistry. They excluded in vitro studies, case series, case reports, letters to editors (not containing primary data), editorials, review articles and commentaries, but read them to identify any potential studies.

Results. The authors searched 98 articles for relevance, determined according to title, abstract and full text, resulting in a yield of 12 original studies. Nine were clinical trials that focused on caries prevention, seven of which showed that CPP-ACP (as found in sugar-free pellet or slab chewing gum, lozenges, milk or mouthrinse) was effective in preventing dental caries by remineralizing subsurface carious lesions in situ in a dose-response fashion. One was a clinical trial with conflicting results regarding the effect of CPP-ACP on the regression of white-spot lesions; one was a survey of the relief of dry-mouth symptoms; and one was an uncontrolled clinical study that showed the lack of effectiveness and lack of short-term therapeutic effect in treating dentin hypersensitivity.

Clinical Implications. The quantity and quality of clinical trial evidence are insufficient to make conclusions regarding the long-term effectiveness of casein derivatives, specifically CPP-ACP, in preventing caries in vivo and treating dentin hypersensitivity or dry mouth.

Key Words: Anticariogenicity; casein derivative; casein phosphopeptide–amorphous calcium phosphate; remineralization; demineralization; systematic review

Abbreviations: CaCO3: Calcium carbonate • CaHPO4/CaCO3: Calcium hydrogen phosphate/ calcium carbonate • CD-CP: Casein derivatives coupled with calcium phosphate • CPP-ACP: Casein phosphopeptide–amorphous calcium phosphate • FDA: Food and Drug Administration • NaF: Sodium fluoride • RCT: Randomized controlled trial • WSL: White-spot lesion






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright©1995-2008 American Dental Association (ADA).
Reproduction or republication strictly prohibited without prior written permission of ADA.