The Jorgensen technique and nitrous oxide-oxygen sedation were evaluated for the risk of aspiration. Volunteers and patients were studied in the supine, semisupine, and Trendelenburg positions. Aspiration occurred in a single patient under the Jorgensen technique and could be related to the presence of a narcotic in the mixture. The incidence of tracheal soiling was lower than that with other intravenous techniques and could be attributed to the use of the semisupine position or the baseline concept of narcotic dosage in the Jorgensen technique. In the nitrous oxide-oxygen sedation technique, aspiration was not noted. The study suggests that use of a narcotic in an intravenous sedative technique increases the hazard of aspiration.