The Journal of the American Dental Association
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J Am Dent Assoc, Vol 137, No 7, 944.
© 2006 American Dental Association
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LETTERS

ORAL SEDATION

I read with great interest the excellent article on oral sedation by Dr. Raymond Dionne and colleagues in March JADA.1 However, the authors do not discuss the important interaction of orally-administered triazolam and other benzodiazepines with grapefruit and other citrus products.2–5 Dr. David Bailey and his colleagues have shown that this well-established interaction may increase these drugs’, clinical bio-availability and risk of toxicity.


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  1. Dionne RA, Yagiela JA, Coté CJ et al. Balancing efficacy and safety in the use of oral sedation in dental outpatients. JADA 2006;137:502–13.[Abstract/Free Full Text]

  2. Bailey DG, Dresser GK. Natural products and adverse drug interactions. Can Med Assoc J 2004;170:1531–2.[Free Full Text]

  3. Flanagan D. Oral triazolam sedation in implant dentistry. J Oral Implantol 2004; 30:93–7.[Medline]

  4. Bailey DG. Grapefruit juice-drug interaction issues. In: Boullata JI, Armenti VT, eds. Handbook of drug-nutrient interactions. Totowa, NJ: Humana; 2004:9.

  5. Flanagan D. Understanding the grapefruit-drug interaction. Gen Dent 2005;53:282–5.[Medline]



Dennis Flanagan, DDS
Willimantic, Conn.


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K. Hosaka, D. Jackson, J. E. Pickrell, M. Heima, and P. Milgrom
Flumazenil Reversal of Sublingual Triazolam: A Randomized Controlled Clinical Trial
J Am Dent Assoc, May 1, 2009; 140(5): 559 - 566.
[Abstract] [Full Text] [PDF]

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