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J Am Dent Assoc, Vol 138, No 2, 202-208.
© 2007 American Dental Association
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CLINICAL PRACTICE

Cost-effectiveness of treatments for temporomandibular disorders Biopsychosocial intervention versus treatment as usual



Anna Wright Stowell, PhD, Robert J. Gatchel, PhD and Lynn Wildenstein, MA


   ABSTRACT
TOP
 ABSTRACT
SUBJECTS AND METHODS
 RESULTS
 DISCUSSION
 CONCLUSION
 REFERENCES
 
Background. The authors conducted a randomized clinical trial to evaluate the cost-effectiveness of a biopsychosocial intervention with patients who are at high risk (HR) of progressing from acute to chronic TMD-related pain.

Methods. The authors classified 96 patients with acute TMD (less than six months’ duration) as HR according to a predictive algorithm and randomized them into an early intervention (EI) or a nonintervention (NI) group. The NI group received a biopsychosocial treatment that included cognitive behavioral skills training and biofeedback. Both groups were followed up for one year. The authors collected TMD cost data throughout the year.

Results. The authors found that the EI group spent significantly fewer jaw-related health care dollars, relative to the NI group, from intake to the one-year follow-up.

Conclusion and Clinical Implications. The reduced jaw-related health care expenditures for patients in the EI group compared with expenditures for patients in the NI group at one year suggest that an early biopsychosocial intervention is a cost-effective measure in dealing with often unnecessarily costly TMD-related pain.

Key Words: Temporomandibular pain; health care costs; conservative treatment; early intervention

Abbreviations: BDI-2: Beck Depression Inventory-2 • CPI: Characteristic Pain Inventory • EI: Early intervention • EOBs: Explanations of benefits • HR: High risk • LOCF: Last-observation-carried-forward • NI: Nonintervention • TMDs: Temporomandibular disorders • WOC: Ways of Coping-Revised

Temporomandibular disorders (TMDs), a group of disorders involving the muscles of the face, head, neck and temporomandibular joint,1 are the second most commonly occurring musculoskeletal condition resulting in pain and disability (the first is chronic low back pain2).

TMD affects about 10 to 15 percent of the U.S. population,3–5 with an annual cost estimated at $4 billion.6 Only a minority of patients who seek treatment eventually progress to the stage of chronic TMD.7 However, chronic TMD can lead to significant costs stemming from multiple treatments from a variety of health care providers and from lost wages.8 For this reason, cost-effective early intervention is necessary to cut the enormous costs of this class of disorders, as well as to decrease unnecessary and prolonged suffering in patients with TMD.

Studies of patients with TMD have found that these disorders affect the social, vocational and emotional lives of patients; if TMD progresses to a chronic condition, it can become seriously debilitating and disruptive to everyday life.1,9,10 When TMD becomes chronic, seeking treatment from clinicians who do not recognize the biopsychosocial aspects of these disorders can set up a revolving door, with the patient visiting provider after provider in the wake of treatment failures that can exacerbate the patient’s distress.8

As the patient’s pain increases without resolution, a domino effect takes place, consisting of increased pain duration, health care utilization, distress and, ultimately, costs. Few cost data are available for patients with TMD. However, Brotman11 found that managed care treatment costs for TMD ranged from $12,000 to $20,000 annually per patient. Moreover, studies have found that patients with TMD have significantly higher rates of utilization of health care services than do patients without TMD.12–14

For example, White and colleagues12 studied 8,891 members of a health maintenance organization during a six-year period and found that patients with TMD used more of all types of services (not just TMD-related) than did control subjects in inpatient, outpatient and pharmaceutical groups. Similarly, Shimshak and colleagues14 analyzed data from a Blue Cross/Blue Shield health plan and found that members who had submitted at least one health care claim for TMD had twice the rate of reimbursement for all medical claims compared with members who had no TMD claims. Furthermore, Shimshak and DeFuria13 analyzed claims submitted to a New England health care insurer and found that members with one or more TMD claims used more health care services and had higher associated costs than did a comparison group with no TMD-related claims. In addition to incurring higher costs for health care services, patients with TMD use more sick leave than do patients without TMD.15

The costs of treatment for TMD are of particular concern because most insurance companies do not cover treatment associated with this diagnosis, and insurance laws regarding coverage vary by state.16 Because of the multifactorial nature of these disorders, medical and dental insurance carriers typically pass the liability of TMD to each other, resulting in a situation in which both carriers refuse to pay. This leaves the patient fully responsible for what often is costly treatment.17 Furthermore, as the above utilization figures indicate, if adequate treatment is not received, patients with TMD are likely to use more non-TMD medical services.

The purpose of our study was to analyze expenditures for patients with TMD who had received a biopsychosocial intervention in the acute phase of the disorder, relative to expenditures for those who did not receive this intervention. The effectiveness of the biopsychosocial intervention used in this study has been reported elsewhere.6 Gatchel and colleagues6 found that early intervention, using a standardized treatment protocol manual and based on a biopsychosocial approach (thus ensuring that all study subjects received the same treatment), was effective in reducing pain and decreasing the progression to chronic stages of TMD. Clearly, if the duration of pain decreases, so will the total associated costs. In a follow-up of patients in our earlier study, we aim to document the cost-effectiveness of this intervention.


   SUBJECTS AND METHODS
TOP
 ABSTRACT
 SUBJECTS AND METHODS
RESULTS
 DISCUSSION
 CONCLUSION
 REFERENCES
 
Subjects. We obtained the subject cohort from a larger, ongoing study.6 Of subjects in the larger study, now composed of 113 patients considered to be at high risk (HR) of developing acute jaw pain, 96 were included in this smaller study, because financial data were available for them. We randomly assigned the HR patients to early intervention (EI) and nonintervention (NI) groups. The final sample was composed of 76 women and 20 men; the mean age was 37.54 years, with a range of 18 to 60.88 years.

General dentists and oral surgeons in a major urban metropolitan area referred patients to the TMD Clinical Research Project at the University of Texas Southwestern Medical Center at Dallas, or patients responded to flyers and other advertising in the local media. Inclusion criteria for the study were that subjects had to be between the ages of 18 and 70 years and have acute jaw or facial pain (defined as present for less than six months). Two of us (A.W.S., L.W.) screened potential subjects and excluded them if they reported comorbid pain or exacerbating physical conditions, such as fibromyalgia, chronic low back pain or cancer, or if they had had any history of jaw pain before the current episode.

Methods. We conducted this cost analysis as an extension of our ongoing acute jaw pain study discussed above.6,17 In summary, two of us (A.W.S., L.W.) followed up subjects with acute jaw pain from the initial intake through telephone follow-up calls every three months and a final follow-up visit at one year. During the initial intake and at the one-year follow-up visit, one of us (L.W.) interviewed subjects in person, and they completed a battery of psychosocial tests, underwent a jaw examination using the research diagnostic criteria,6,17 and provided medical histories of their jaw pain and health care utilization. Psychosocial measures included the following: the Characteristic Pain Inventory (CPI),18 a pain intensity measure; the Beck Depression Inventory-2 (BDI-2),19 a self-reported measure of depression; and the Ways of Coping-Revised (WOC),20 a self-reported measure of coping that assesses five styles categorized into adaptive and maladaptive coping styles. A more complete description of these measures is provided elsewhere.6

We randomly assigned patients who were determined at intake to be at risk of progressing to chronic TMD to an EI or NI group. We made this determination using an algorithm that consisted of a two-variable predictive model (presence of a muscle disorder and characteristic pain intensity). A more complete description of this algorithm is found elsewhere.21 Those assigned to the EI group participated in a module-driven biopsychosocial treatment that included cognitive-behavioral skills training and biofeedback, divided into six weekly sessions (a more comprehensive description of this treatment is provided in our earlier report6). We encouraged all subjects to receive any treatment "as usual" as prescribed by any outside health care providers with whom they had consulted or were continuing to consult. We intended study participation to be an adjunct to patients’ ongoing care.

Cost data. We collected financial information at intake for the three-month period preceding the onset of pain and up to the intake appointment. Because we included subjects in the study only if their onset of pain occurred no longer than six months before the intake appointment, the financial information could have been for a period ranging from one day to nine months. We asked subjects to bring to the intake interview receipts and/or explanations of benefits (EOBs) for all expenditures for jaw treatment. We then asked subjects to maintain financial records of any jaw treatment received throughout the following year. In addition, subjects signed a medical release of information so that we could access information at one year even if subjects were unable to provide the data themselves.

At the three-, six- and nine-month follow-up contacts, we interviewed patients on the telephone regarding their current level of pain and their utilization of health care services. We asked them to differentiate between services used for the jaw and those used for other health issues. At the one-year follow-up visit, we asked subjects to bring receipts and/or EOBs for jaw treatment expenses incurred since their intake visit. For subjects who were unable to provide receipts for services, we used the medical release to obtain information from the treating health care professional.

EI group. We collected financial data only at the intake and one-year follow-up appointments. Within the EI group, we obtained financial data from 57 subjects at intake and 53 subjects at the one-year follow-up visit. Reasons for missing data at the one-year follow-up were as follows: one subject dropped out of treatment and we were unable to contact him at any follow-up time (that is, the three-, six- or nine-month contacts or the one-year visit); one subject completed treatment and the telephone contacts but we could not contact her for the one-year follow-up appointment; and two subjects had not reached the projected one-year follow-up visit by the time we wrote this report.

NI group. We obtained financial data from 39 subjects in the NI group at intake and from 37 subjects at the one-year follow-up visit. Reasons for missing data at the one-year follow-up were as follows: one subject had not reached the projected one-year follow-up visit by the time we wrote this report, and one subject could not recall or locate information.

Consistent with our previous report,6 we used an intent-to-treat statistical method to calculate the projected one-year follow-up results for the four subjects in the EI group and the two subjects in the NI group for whom data were missing. The statistical method used was the last-observation-carried-forward (LOCF) approach in which missing values are replaced with the last nonmissing value.22 There were no statistical differences between patients who completed the one-year follow-up (n = 86) and those who did not (n = 7) with regard to primary demographic variables (three patients were not eligible for the one-year follow-up visit at the time of the analyses).


   RESULTS
TOP
 ABSTRACT
 SUBJECTS AND METHODS
 RESULTS
DISCUSSION
 CONCLUSION
 REFERENCES
 
Demographic characteristics. Table 1Go presents the demographic characteristics of patients in the EI and NI groups. We found no significant differences between these groups at baseline with regard to sex, race, marital status, employment status, health insurance status, age, monthly income before taxes, referral type (dental versus nondental provider) and duration of jaw pain.


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  		TABLE 1 Demographic data.

 
Major pain and psychosocial outcomes. Table 2Go presents the mean scores and standard deviations for the major outcome measures reported in our earlier study.6 We should point out that these scores changed somewhat because of the slightly different cohort used in this study. All of the results, however, are consistent with those of the earlier study. As in our earlier study, these results show significant differences between the two groups with regard to self-reported pain (CPI), depression (BDI-2) and problem-focused coping (WOC).


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  		TABLE 2 Summary scores of various measures at intake and one-year follow-up visit, by group.*{dagger}

 
Cost data. In terms of the total amount of health care dollars spent on treatment related to jaw pain, only the EI group exhibited a significant reduction in TMD-related health care expenses from intake to the one-year follow-up visit (Table 3Go). Because the NI group had lower costs at the intake visit than did the EI group, we applied an analysis of covariance to these data, using the intake amount as the covariate. This analysis confirmed the lower costs at follow-up associated with the EI group for treatment related to jaw pain (F1,93 = 5.64, P = .029). We also should point out that, because these data revealed that the mean costs decreased from intake to the one-year follow-up for both groups, we can view the LOCF method used for missing data as a conservative approach.22


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  		TABLE 3 Cost data, by group.

 
Table 4Go (page 207) provides a summary of health care visits related to jaw pain, according to various types of providers (for example, general dentists, orthodontists, oral surgeons, chiropractors) outside the study, during the period from onset of pain to intake and during the period from intake to the one-year follow-up visit. As the table shows, patients visited a wide array of health care providers in search of treatment to reduce their jaw pain. We also conducted an analysis to compare the mean proportion of visits in the EI group that were non–TMD-related with that in the NI group. The results showed no significant differences (t94 = 0.91, P = .36). Thus, the type of health care visit (that is, TMD-related versus non–TMD-related) was comparable between the two groups.


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  		TABLE 4 Jaw pain–related health care visits before intake and between intake and one-year follow-up visit.

 
Finally, we also addressed the question of whether the reduced health care costs for the EI group could be attributed directly to changes in pain and depression symptomatology. We performed multiple regression analyses for this purpose. For the association between change in costs and change in BDI-2 from intake to the one-year follow-up visit, to control for differences in groups (EI versus NI), we included group as an independent variable in the model. The results indicated that the BDI-2 was not a significant predictor when we controlled for group (t1 = 0.62, P = .54). Similarly, we found no significant relationship between the CPI and costs (after controlling for the group) (t1 = 0.16, P = .87).


   DISCUSSION
TOP
 ABSTRACT
 SUBJECTS AND METHODS
 RESULTS
 DISCUSSION
CONCLUSION
 REFERENCES
 
Controversy regarding the treatment of TMD is a longstanding issue among researchers and clinicians.23,24 Despite this, beginning in the late 1990s, a trend toward more conservative forms of treatment (versus the more invasive treatments of the past) has emerged.25–28 Stohler and Zarb,24 in their insightful article about this controversy, make a plea for a "low-tech, high prudence therapeutic approach." Cognitive-behavioral approaches have been identified as conservative interventions that have been helpful to many patients with TMD.6,7,29–31 However, no studies, to our knowledge, have assessed the cost-benefit ratio of these treatments.

Cognitive-behavioral interventions. The findings of our study suggest that cognitive-behavioral interventions represent not only therapeutically efficacious treatment for TMD, as evidenced by outcomes reported earlier,6 but also cost-effective treatment, particularly when used in the acute stage of the dysfunction. Our findings demonstrate that subjects who received the six-session, noninvasive early intervention reduced their TMD-related health care costs significantly in the year after the onset of pain.

Of course, this study evaluated early biopsychosocial intervention for HR patients only. We would expect even low-risk patients to benefit; however, future studies will need to investigate this. Moreover, as noted in our earlier study,6 we did not include an attention-placebo (that is, an ineffectual but harmless treatment) because of ethical issues. Therefore, some may view the NI group as a less-than-conservative contrast (that is, they did not receive a similarly time-demanding intervention).

In addition, this study intentionally excluded patients with fibromyalgia, which may have further contributed to an overly conservative estimate of the ratio between treatment benefits and costs. That said, although health care providers often identify a comorbidity of TMD and fibromyalgia, one study found that, among a group of patients with a primary diagnosis of fibromyalgia, TMD frequently co-occurred (24 percent). In contrast, among a group of patients with a primary diagnosis of chronic TMD, the rate of co-occurrence with fibromyalgia was much lower (9 percent).32 Therefore, based on these findings of Aaron and colleagues,32 we can conclude that patients who have TMD as a primary diagnosis may be a "less sick" group than patients with fibromyalgia, who typically have a relatively high co-occurrence of multiple diagnoses, including irritable bowel syndrome and chronic low back pain.

In addition, all studies identified thus far focused exclusively on chronic pain conditions, whereas the intent of our study was to evaluate patients early in the pain process. Therefore, to allow for generalization of results among patients with acute jaw pain, we excluded people with chronic pain symptom patterns.

Study limitations. One potential limitation of our study was the method of collecting cost data, which relied on subjects to provide receipts and insurance EOB statements, as well as on our own review of providers’ billing records. Although these billing records are a good source of information, they were not available for all subjects. This leads to the difficulty with the first source of data, which may involve human error in recall and memory (for example, some patients may not have remembered to keep or bring receipts, and patients had to recall dates of service). Indeed, some people had missing data for various reasons. However, we found no differences between those missing one-year data and those who had the one-year data. Still, future studies should focus on more aggressive data collection efforts to strengthen our findings.

In addition, we intend to follow up these patients with acute jaw pain for another year to determine if subjects in the EI group continue to experience reduced health care costs and if subjects in the NI group experience rising or stable costs. Future studies also should seek to include the cost of the intervention itself to provide a more comprehensive evaluation of the cost-effectiveness of early intervention among patients with jaw pain.


   CONCLUSION
TOP
 ABSTRACT
 SUBJECTS AND METHODS
 RESULTS
 DISCUSSION
 CONCLUSION
REFERENCES
 
The reduced jaw-related health care expenditures for patients in the EI group compared with those for patients in the NI group at one year suggest that an early biopsychosocial intervention is a cost-effective method of treating TMD-related pain that often involves unnecessarily high costs. Clinicians need to consider such an approach when developing treatment plans for these difficult-to-treat patients.


   FOOTNOTES
 

Dr. Stowell is an assistant professor, departments of Anesthesiology and Pain Management, Psychiatry, and Rehabilitation Counseling, and the director of Behavioral Medicine Services at The Eugene McDermott Center for Pain Management, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., MC 9189, Dallas, Texas 75390-9189, e-mail "anna.stowell{at}utsouthwestern.edu". Address reprint requests to Dr. Stowell.


Dr. Gatchel is a professor and the chairman, Department of Psychology, College of Science, University of Texas at Arlington; a clinical professor, Department of Anesthesiology and Pain Management, and the clinical research director at The Eugene McDermott Center for Pain Management, University of Texas Southwestern Medical Center at Dallas.


The late Ms. Wildenstein was a research associate, Department of Psychology, College of Science, University of Texas at Arlington.


This study was supported, in part, by National Institutes of Health grants 2 R01 DE10713, 3 R01 MH 46452 and 1 K05 MH 071892.


This article is dedicated to the memory of Lynn Wildenstein.


   REFERENCES
TOP
 ABSTRACT
 SUBJECTS AND METHODS
 RESULTS
 DISCUSSION
 CONCLUSION
 REFERENCES
 

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