HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

J Am Dent Assoc, Vol 137, No 3, 313-321. © 2006 American Dental Association

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wong, D. T. Search for Related Content PubMed PubMed Citation Articles by Wong, D. T. Related Collections Periodontics

Background. The ability to monitor health status, disease onset and progression, and treatment outcome through noninvasive means is a highly desirable goal in health care promotion and delivery. Oral fluid is a perfect medium to be explored for health and disease surveillance.

Methods. Two prerequisites exist before the goal of salivary diagnostics can be achieved: identification of specific biomarkers associated with a health or disease state and the development of technologies that can discriminate between the biomarkers. A recent initiative of the National Institute of Dental and Craniofacial Research has created a roadmap to achieve these goals through the use of oral fluids as the diagnostic medium to scrutinize the health and/or disease status of patients. This is an ideal opportunity to optimize state-of-the-art saliva-based biosensors for salivary biomarkers that discriminate between diseases.

Results. Seven technology groups are developing point-of-care salivary diagnostic technologies. Three groups are working together toward deciphering the salivary proteome.

Conclusion. These collective efforts and the convergence of salivary diagnostic technologies and the salivary proteome will present unparalleled opportunities to explore the diagnostic potential of saliva for oral and systemic diseases.

Key Words: Oral fluid; saliva; oral cancer; nanotechnology; proteomics; genomics

This article has been cited by other articles:

				F. Wei, J. Wang, W. Liao, B. G. Zimmermann, D. T. Wong, and C.-M. Ho Electrochemical detection of low-copy number salivary RNA based on specific signal amplification with a hairpin probe Nucleic Acids Res., June 1, 2008; 36(11): e65 - e65. [Abstract] [Full Text] [PDF]

				A. M. Iacopino The Influence of "New Science" on Dental Education: Current Concepts, Trends, and Models for the Future J Dent Educ., April 1, 2007; 71(4): 450 - 462. [Abstract] [Full Text] [PDF]

				A. E. Herr, A. V. Hatch, D. J. Throckmorton, H. M. Tran, J. S. Brennan, W. V. Giannobile, and A. K. Singh Microfluidic immunoassays as rapid saliva-based clinical diagnostics PNAS, March 27, 2007; 104(13): 5268 - 5273. [Abstract] [Full Text] [PDF]

				C. Solomon, J. Poole, K. T Palmer, and D. Coggon Health-related job loss: findings from a community-based survey Occup. Environ. Med., March 1, 2007; 64(3): 144 - 149. [Abstract] [Full Text] [PDF]

				L. Seugnet, J. Boero, L. Gottschalk, S. P. Duntley, and P. J. Shaw Identification of a biomarker for sleep drive in flies and humans PNAS, December 26, 2006; 103(52): 19913 - 19918. [Abstract] [Full Text] [PDF]